【摘 要】
：
As the prolactin receptor (PRLR) signaling was proved to be involved in breast and prostate tumorigenesis, there is a real need to develop therapeutic strategies to block its activation.The active com
【机 构】
：
University Paris Descartes France
【出 处】
：
2013第三届内分泌与代谢大会暨2013第二届糖尿病大会
论文部分内容阅读
As the prolactin receptor (PRLR) signaling was proved to be involved in breast and prostate tumorigenesis, there is a real need to develop therapeutic strategies to block its activation.The active complex between prolactin (PRL) and its receptor is a heterotrimer involving one hormone molecule and two receptor moieties.The ligand-receptor interacting interfaces are called binding sites 1 and 2.In order to develop pure PRLR antagonists, we first started with the strategy used for the homologous growth hormone receptor consisting in mutating the Glycine lying at the bottom of the hormone site 2 cavity by an Arginine.
其他文献
Trying to solve the main bottle neck of Brazilian beef industry our research team is dedicate to study Nellore puberty.Although very resistant to environmental pressure Nellore cattle is one year behi
In the course of care and evaluation of thyroid function, several nursing home residents were unexpectedly found to have secondary hypothyroidism.Further laboratory evaluation of their pituitary funct
Our knowledge of adipose tissue has changed from an inert energy storage tissue to an active endocrine organ, which communicates with central and peripheral organs through the synthesis and secretion
Tamoxifen remains the first line therapy for estrogen receptor positive (ER+) breast cancer.However, polymorphisms of the gene encoding P450 2D6 could result in no protein expression or no CYP2D6 enzy
Oxidative stress has been identified to play a causal role in insulin resistance.As a major endogenous anti-oxidative system, the function of nuclear factor-erythroid 2-related factor 2 (Nrf2) could b
The ubiquitin-proteasome and autophagy-lysosome systems are major proteolytic pathways.Autophagy has recently emerged as an important regulatory pathway of lipid metabolism.Here, we investigated roles
Obesity-induced chronic inflammation is deeply involved in insulin resistance, type 2 diabetes, and cardiovascular disease.A significant advance in our understanding of obesity-associated inflammation
Acromegaly is a chronic and multisystemic disease having a high rate of morbidity and mortality due to cardiovascular, respiratory and metabolic causes.Although it is described an increase in benign a
Breast cancer is the most common cancer in developed countries.In Singapore, age standardized rates (per 100,000/year) for breast cancer has risen almost three-fold from 20.0 to 58.5 per 100,000/year
Traditional literature and textbooks generally describe that testosterone (T) is the main substrate for the biosynthesis of estradiol (E2), the most potent natural estrogen and dihydrotestosterone (DH