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  5. Targeting patient-derived glioblastoma stem cells by CD133-specific CAR T cells

Targeting patient-derived glioblastoma stem cells by CD133-specific CAR T cells

来源 :上海浦东免疫化学国际生物论坛 | 被引量 : 0次 | 上传用户：anandebaobei
【摘 要】
：
The AC133 epitope of CD133 is a cancer stem cell (CSC) marker for many tumor entities, including the highly malignant glioblastoma multiforme (GBM).We have deve
【作 者】
：
Xuekai Zhu Gabriele Niedermann 
【机 构】
：
DepartmentofRadiationOncology,UniversityHospitalFreiburg,Freiburg,Germany;GermanCancerConsortium(DKT
【出 处】
：
上海浦东免疫化学国际生物论坛
【发表日期】
：
2015年11期
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论文部分内容阅读
The AC133 epitope of CD133 is a cancer stem cell (CSC) marker for many tumor entities, including the highly malignant glioblastoma multiforme (GBM).We have developed an AC133-specific chimeric antigen receptor (CAR) and show that AC133-CAR T cells kill AC133+ GBM stem cells (GBM-SCs) both in vitro and in an orthotopic tumor model in vivo.
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