【摘 要】
：
Objective: To elevate expression of MyD88 was found in HCC patients.Tumor growth and metastasis may be attributed to such increased expression.Methods: For the in vitro study, a synthesized MyD88 inhi
【机 构】
：
Key Laboratory of Organ Transplantation,Ministry of Education;Key Laboratory of Organ Transplantatio
【出 处】
：
22nd Asia Pacific Cancer Conference(第22届亚太抗癌大会)
论文部分内容阅读
Objective: To elevate expression of MyD88 was found in HCC patients.Tumor growth and metastasis may be attributed to such increased expression.Methods: For the in vitro study, a synthesized MyD88 inhibitor was incubated with murine hepatocyte carcinoma H22 cells for2, 4, 16, 24, and 30 h separately.The working concentrations of the synthesized MyD88 inhibitor were set to 20, 40, and 80μM.Cell proliferation and cell viability were estimated by BrdU assay and Alamar Blue analysis.For the in vivo study, 2x10s H22 cells were pre-treated with 40 μM MyD88 inhibitor for4 h and subcutaneously injected into the BALB/c mice.The tumor growth and the tumor size of BALB/c mice generated by MyD88 inhibitor-treated H22 cells were compared with those generated by untreated H22 cells.To estimate the antitumor effects of MyD88 inhibitor, tumor formation was established in a BALB/c mouse by H22 cells and then basally injected with MyD88 inhibitor.Tumor-bearing mice without MyD88 inhibitor treatment were used as controls.
其他文献
Stereotactic body radiation therapy (SBRT) is an emerging technique used to treat medically inoperable early stage non-small cell lung cancer (NSCLC).Studies have reported that the local control rate
Recent studies identified a group of structurally diverse muhifunctional host proteins rapidly released following pathogen challenge or cell injury and, most importantly, able to chemotactically recru
In the past, radiotherapy was seldom applied to treat hepatocellular carcinoma (HCC).With the advances in radiotherapeutic technology, stereotactic ablative radiotherapy(SABR) has been applied success
Nanotechnology-based delivery systems were intensively studied for application on chemotherapy and photodynamic therapy.Hematoporphyrin (HP), a major molecule in erythrocyte, was used in photodynamic
Myocardial infarction (MI) mainly causes morbidity and mortality in heart patients.Approaches such as protein delivery and stem cell therapy were studied to treat cardiovascular diseases.Significance
Objective: To determine the status of nurses who educate patients to provide the basis of a patient education plan regarding safe sexual behavior.Methods: In this study, an interview was conducted and
Objective: The Ras superfamily is divided into five principal subfamilies, namely, Ras, Rho, Rab, ADP-ribosylation factor, and Ran.These proteins have important functions in diverse cellular and devel
Objective: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide and is among the leading causes of cancer-related deaths, especially in China.Systemic and targeted therapies, suc
Objective: The overexpression of thioredoxin (Trx) 1, which is a ubiquitously expressed small redox protein, is one of the mechanisms of drug resistance in hepatocellular carcinoma(HCC) treatment.The
Objective: To expand cord blood natural killer (CB-NK) cells and enhance CB-NK cytotoxicity against hematological tumor cells.Methods: CB-NK cells were expanded with irradiated K562-mbl5-41BBL celllin