Intratumor BCG administration eradicates local as well as metastasized tumors.Administration of BCG into noncancerous tissues, however, results in no effect on the tumors.Inflammation induced by BCG in normal tissues releases lysophospholipids that activate macrophages.Because cancerous tissues contain alkylphospholipids, BCGinduced inflammation of cancerous tissues produces alkyl-lysophospholipids that activate macrophages approximately 400 times more effective than lysophospholipids, implying that highly activated macrophages are tumoricidal.Inflammation-primed macrophage activation is the principal macrophage activation process that requires serum vitamin D-binding protein (known as Gc protein) which is the precursor for the macrophage activating factor (MAF).