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  5. Targeted Inhibition of ATP-Binding Cassette Transporter A1 Protein Degradation Promotes Reverse Chol

Targeted Inhibition of ATP-Binding Cassette Transporter A1 Protein Degradation Promotes Reverse Chol

来源 :The 6th China-Russia International Conference on Medicine(第六 | 被引量 : 0次 | 上传用户：tianzhiziyao
【摘 要】
：
Aim: ABCA1 is a 2,261-amino-acid integral membrane protein that comprises two halves of similar structure.Each half has a transmembrane domain containing six helices and a nucleotide binding domain (N
【作 者】
：
Lin-Zhang Huang Bao-Yan Fan Hai-Bo Zhu 
【机 构】
：
State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing key labora
【出 处】
：
The 6th China-Russia International Conference on Medicine(第六
【发表日期】
：
2014年3期
【关键词】
：
Calpain-mediated protein degradation cholesterol efflux Atherosclerosis Macropha 
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Aim: ABCA1 is a 2,261-amino-acid integral membrane protein that comprises two halves of similar structure.Each half has a transmembrane domain containing six helices and a nucleotide binding domain (NBD) containing two conserved peptide motifs known as Walker A and Walker B, which are present in many proteins that utilize ATP, and a Walker C signature unique to ABC transporters.
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