【摘 要】
:
The 3D genome organization plays an essential role in orchestrating the many essential nuclear processes including gene regulation.Great strides have been made
【机 构】
:
UniversityofCalifornia
【出 处】
:
The 4th International Conference of Genomics Beyond Biologic
论文部分内容阅读
The 3D genome organization plays an essential role in orchestrating the many essential nuclear processes including gene regulation.Great strides have been made recently to characterize the 3D chromatin architecture in mammalian cells,with the development of both technologies for genome-wide study of chromatin interactions at increasing precision and concepts such as "chromosome territories","topologically associating domains" and "chromatin loops".I will discuss how these new concepts are transforming the study of gene regulatory mechanisms in mammalian cells,by giving specific examples that illustrate the role of 3D chromatin organization in developing revolutionary tools in sequencing diploid genomes,understanding molecular basis of genetic disorders caused by genome structural variations,and predicting target genes of enhancers.
其他文献
主要组织相容性复合体(MHC)是重要的抗原提呈类分子,而MHCⅡ类分子在成熟装配过程中其多态性α、β链与γ链(即恒定链,又称Ii链)组成的九聚体。其中α和β链对动物抗病/易感性
Omics studies is experiencing an explosive increase during the last decades and the journal Genomics,Proteomics & Bioinformatics (GPB) has witnessed the fast dc
The advancement of high throughput sequencing technology coupled with internet technology has enabled us to acquire massive genomic data for in-depth understand
The giant panda is not only the symbol of the world biodiversity conservation,but also the model to address questions of the evolutionary biology,especially the
水稻作为我国最主要的粮食作物之一,是我国粮食安全和农业可持续发展的重要战略资源。长期以来,稻瘟病、纹枯病、白叶枯病等真菌性或者细菌性病害严重限制了水稻的产量和品质。通过基因工程克隆抗病基因并与常规育种技术相结合培育抗病新品种是现代作物遗传改良的有效途径。本研究拟从辣椒中分离出的广谱抗病基因(抗菌蛋白、硫素蛋白、亲环蛋白、铁氧还蛋白、非特异性脂转移蛋白)与强诱导型启动子LURP1(Late Upre
阿维菌素是一种新型、高效、高选择性、安全的农畜两用类药物,已在国内外得到广泛应用。然而,阿维菌素具有遇光易分解、半衰期短、剂型在靶标上停留时间短等缺点,本研究针对以上问题,通过功能高分子材料的设计和制备,开创性地发现了聚多巴胺具有自引发光接枝光聚合(SIPGP)的特性,结合多巴胺容易氧化自聚合成膜和粘附性特点,制备了具有紫外屏蔽性能、在不同界面都具有良好粘附性能且可以控制释放的三种新型阿维菌素剂型
碳酸二甲酯和碳酸二苯酯是两种重要的绿色化工产品.甲醇氧化羰基合成碳酸二甲酯工艺以及草酸二苯酯与苯酚酯交换法合成碳酸二苯酯工艺越来越受到国内外研究人员的青睐.在反应
In life science more and more high-throughput approaches are developed,matured and applied to generate substantial data sets.Two prominent examples include next
该文对喷射型立体传质塔板的传质性能进行了实验研究,所得到的实验结果对今后进一步开发出高效喷射型立体传质塔板具有指导作用.该文在垂直于塔板方向上对喷射型立体传质塔板
The understanding of the genetic and epigenetic mechanisms responsible for human cardiomyopathies,which are responsible for the largest fraction of sudden cardi