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BldD (SACE_2077),a key developmental regulator in actinomycetes,is the first identified transcriptional factor in Saccharopolyspora erythraeapositively regulating erythromycin production and morphological differentiation.Although the BldD of S.erythraea binds to the promoters of erythromycin biosynthetic genes,the interaction affinities are relatively low,implying the existence of its other target genes in S.erythraea.