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Cancer theranostics represents the nanotechnology-based multimodal approaches to deliver combined diagnostic and therapeutic agents to the tumor site with high specificity and in adequate concentrations to realize the promise of combined diagnosis and treatment in a single sitting.We have encapsulated multiple imaging and therapeutic agents in biocompatible and biodegradable poly lactic-co-glycolic acid (PLGA) microbubbles (size: 2-5 m) and nanobubbles (size: 100-300 nm) for multimodal imaging, therapeutic margin assessment, and image-guided drug delivery [1-2].