【摘 要】
：
Adipose tissue synthesizes and secretes numerous hormones or cytokines (adipokines) that play a major role in the maintenance of energy homeostasis in our b
论文部分内容阅读
Adipose tissue synthesizes and secretes numerous hormones or cytokines (adipokines) that play a major role in the maintenance of energy homeostasis in our body.Recent studies suggest that there is a distinct new type of brown fat, the beige fat, which has great therapeutic potential for the treatment of obesity and its related metabolic disorders.Over the past ten years, a great progress has been made on our understanding of adipocyte development, differentiation, hypertrophy, as well as the development of beige fat at the transcriptional level.However, the upstream signaling pathways that regulate adipocyte biology and function and the beigeing process remain unclear.
其他文献
从能量代谢的角度解释肥胖中高血压的发病基础以及降压药作用原理。其中抱括镇静剂,beta受体阻断剂,血管紧张素受体阻断剂等。其中涉及到肥胖时,慢性炎症的起源,慢性炎症
血管内皮细胞的衰老与更新对血管正常生理功能的维持至关重要,衰老与更新的不平衡可能参与动脉粥样硬化和老年性高血压的发生和发展.内皮细胞在体可能进行着复制型衰老和诱导
miRNAs play important roles in regulating differentiation and metabolism of brown adipocytes.We recently identified miR-30 as a key regulator in promoting t
It is generally accepted that insulin resistance in skeletal muscle is a typical feature of T2DM.The molecular mechanism related with the pathological chang
Obesity represents the accumulation of excessive total body fat and is the result of adipocyte hyperplasia and hypertrophy.Lipid droplets are dynamic subcel
Incretins stimulate a decrease in blood glucose levels by stimulating of insulin secretion from pancreatic beta cells.The incretin mimetics (GLP-1 receptor
Type 1 diabetes (T1D)is an autoimmune disease resulting from self-destruction of insulin-producing β-cells.Neutrophils have recently been implicated in bot