The use of rodents has contributed immensely to biomedical science.However,the genetic and physiological differences between primates and rodents—including their neurophysiological functions,metabolic pathways,and drug sensitivities—hamper the extrapolation of results from rodent disease models to direct clinical applications in humans.Thus,the development of non-human primate models that mimic various human systems would accelerate the advance of biomedical research.Some areas of human biology such as early embryonic development,aging,and maternal–fetal interactions would be best studied in a nonhuman primate model.This paper will discuss several promising non-human primate models which would be a powerful human disease model for biomedical research.