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  5. Construction and mechanism of a novel redox-responsive paclitaxel conjugate for efficacy intracellul

Construction and mechanism of a novel redox-responsive paclitaxel conjugate for efficacy intracellul

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：llll9909
【摘 要】
：
Polymer-drug conjugates have demonstrated significant potentials for the delivery of active agents to targets with minimal burst effect during transition.In this study a new bioconjugate HA-ss-PTX was
【作 者】
：
Shaoping Yin Xu Du Juan Li 
【机 构】
：
Department of Pharmaceutics, China Pharmaceutical University, Nanjing, 210009, PR China
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
【关键词】
：
Redox-response HA-ss-PTX conjugates Active tumor targeting Intracellular drug re 
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　　Polymer-drug conjugates have demonstrated significant potentials for the delivery of active agents to targets with minimal burst effect during transition.In this study a new bioconjugate HA-ss-PTX was designed and synthesized with cooperative dual characteristics of active tumor targeting and selective intracellular drug release to improve the antitumor efficacy.
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