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  5. Preparation and characterization of poorly water-soluble drug glipizide solid dispersions using hot-

Preparation and characterization of poorly water-soluble drug glipizide solid dispersions using hot-

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：tianyi03
【摘 要】
：
The study is aim to prepare and characterize solid dispersions of poorly water-soluble drug glipizide with the intention to improve the dissolution rates.The solid disperisions were prepared by hot-me
【作 者】
：
Xiaoyu Wang Xinggang Yang Weisan Pan 
【机 构】
：
School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road, Shenyang, 110016, China
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
【关键词】
：
solid dispersion poorly water-soluble drug glipizide dissolution rate hot-melt e 
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　　The study is aim to prepare and characterize solid dispersions of poorly water-soluble drug glipizide with the intention to improve the dissolution rates.The solid disperisions were prepared by hot-melt extrusion with water-soluble carrier PVP-VA64 in different drug/carrier proportions which are 1∶3,1∶6 and 1∶9,respectively, and different operation temperatures which are 140 ℃, 160 ℃ and 180 ℃ ,respectively.
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