【摘 要】
：
Human kallikrein-related peptidase2 (KLK2) is a trypsin-like serine protease specifically expressed in the prostate gland and are suggested to be involved i
【机 构】
：
Med DiscoverySA Switzerland
【出 处】
：
中国上海第七届国际新药发明科技年会
论文部分内容阅读
Human kallikrein-related peptidase2 (KLK2) is a trypsin-like serine protease specifically expressed in the prostate gland and are suggested to be involved in prostate cancer development where its expression correlates with prostate cancer aggressiveness.The closely related kallikreins KLK4 and KLK14 are also predominantly expressed in the prostate and are suspected to participate in the biology of prostate cancer.MDPK67b is a potent and selective prostatic kallikrein inhibitor intended for use in treatment of prostate cancer.MDPK67b is a genetically engineered serine protease inhibitor which was developed to inhibit human kallikrein 2 (KLK2).MDPK67b is based on the human serpin alphal-Antichymotrypsin (ACT),in which the protease cleavage site within the reactive center loop was replaced with a KLK2-specific pentapeptide selected by phage display.
其他文献
目的 调查上海市以浦东新区为主的部分行政区域中医全科医学人才的工作现状及满意度,为了解上海市及浦东新区社区中医全科人才现状提供参考.方法 2019年12月运用二阶段分层抽
子孙球为仙人掌科仙人掌属多年生肉质常绿草本,多丛生。幼株为球形,老株为圆筒形,球体暗绿色,具棱11～12个,刺锥形,白花着生于球体上部。子孙球生命力极强,繁殖快,在球上极易
Proteins encoded by oncogenes represent suitable drug targets and several have been validated clinically.However,certain non-oncogenes,which are downstream
CPI-613 is a novel anti-tumor compound presumably with a mechanism of action that does not belong to any existing pharmacological class of anti-cancer agent
井岗霉素是上海市农药研究所创制的新农用抗菌素,可防治水稻纹枯病。现将40％井岗霉素A的毒性研究结果报道如下。大、小鼠经口和经皮LD_(50)均>10000mg/kg,对大鼠皮肤无刺激性
Prevention of acute rejection in composite tissue allotransplantation without continuous immunosuppression lacks reports in worldwide literature.Need for ch
1.The multidrug resistance phenomenon (MDR) impairs drug efficiency,leading to chemotherapeutic failure and hence causing a strong impact on disease outcome
Up4A was discovered in 2005 as a novel endothelium-derived contractile factor,EDCF released from endothelial cells (Jankowski et al.Nat Med 11:223 2005).We
尘螨普遍存在于人类居住和工作的环境中,是一种强烈的致敏源,近年来已引起医学界的重视。为了解居室内螨的孳生及季节消长情况,我们于1991年1～12月份对旅店三种不同地面(地毯
Solid surfaces in contact with biological cells play an important role in cell cultures.In vivo,most cells are embedded within an intricate extracellular ma