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HIV-1 depends on host-cell-encoded factors to complete its life cycle.A comprehensive understanding of how viruses manipulate host machineries during the course of HIV-1 infection can facilitate the identification of host targets for antiviral drugs or gene therapy.The cellular protein Nafl(HIV-1 Nef-associated factor 1)is a CRM1(also known as Exportinl)-dependent nucleo-cytoplasmic shuttling protein,and has previously been identified to regulate multiple receptor-mediated signal pathways in inflammation.