Two 57-residue peptides containing four disulfide bonds were recently isolated from black mamba venom (Dendroaspis polylepis polylepis) using a screen to discover novel acid-sensing ion channel (ASIC) inhibitors (1).Mambalgins are potent,rapid and reversible inhibitors of ASIC channels and produce effective analgesia by targeting both central neurons and primary nociceptors through different ASIC channel subtypes (1).