【摘 要】
：
Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the deamination of methylamine and aminoacetone, producing toxic aldehydes, hydrogen peroxide and ammonia.SSAO activity appears to be associated
【机 构】
：
School of Life Science, Beijing Institute of Technology, Beijing 100081, China;Beijing Institute for
【出 处】
：
第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
论文部分内容阅读
Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the deamination of methylamine and aminoacetone, producing toxic aldehydes, hydrogen peroxide and ammonia.SSAO activity appears to be associated with a number of diseases such as diabetes, inflammatory liver disease.There are several inhibitors of SSAO that have been reported previously, all of which are relatively toxic, which limit the study of SSAO and related diseases.In our previous study, the inhibitory effects of fifteen anti-obesity drugs were investigated in vitro to search for selective SSAO inhibitors, the inhibition of SSAO activity by caffeine was confirmed in both an in vitro and an in vivo study.
其他文献
Oxidation of key amino acid residues in bioactive peptides and proteins by endogenous oxidants can leads to life disorders.It is well known that in vivo oxidation of methionine residue in proteins to
Transient ITP (tITP), usually performed in CZE, is a useful on-line sample preconcentration technique for high saline sample.Only a few papers have applied tITP in MEKC especially SDS system.This stud
The sensitivity of a bioanalytical method is critical is defining the PK parameters of a potential new medicine.Low exposure compounds provide one of the most significant analytical challenges due to
Toll like receptor 4 (TLR4) as pattern recognition receptors plays a key role both in innate and acquired immune response [1].The most important and best characterized ligand for TLR4 is exogenous lip
It is well known that the protein, especially the one which has some post-translational modifications, is available to be enriched using some antibody-based techniques.However, only a small portion of
Tiacumicin B (Fig.1) is a broad-spectrum 18-membered macrolides antibiotic especially against diarrhea-associated Clostridium difficile.Currently, it is undergoing phase Ⅲ clinical trials for the trea
Cereal research has shown that whole grain can provide functional healthy benefit to reduce risks of various types of chronic diseases.Further studies indicated whole grain phytochemicals especially a
Nucleic acids containing repetitive tandem guanines can fold into G-quadruplex (G4) motif, which are prevalent in human genome and involve in many important biological processes [1-2].Some groups have
Heterogeneity is an inherent character of cell populations [1].It has been demonstrated that the variability in daunorubicin accumulation (i.e.net uptake) in patients leukemia cells may be related to
A rapid, accurate and sensitive method was developed and validated for simultaneous determination of steroid hormones and endocrine-disrupting compounds in infant urine.The target compounds were extra