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Objective: Cerebrovascular diseases can do great harm to human health including high rate of mutilation and high mortality and so on.Whats the H2S level in acute ischemia patients ? Our Present study is performed in vivo and in vitro to verify the hydrogen sulfide donor S-propargyl-cysteine, also named ZYZ-802, protective effect in ischemia-reperfusion rats and explore its underlying mechanisms as well.