Cyclometalated Ru(Ⅱ)complexes [Ru(L)2(Cl-Ph-βC)]+(L=bpy,dmb)as potent anticancer agents induce apopt

来源 :第十一届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：llz364088963

【摘要】

：

Two β-carboline ruthenium(Ⅱ)complexes,namely,[Ru(L)2(Cl-Ph-βC)](PF6),where N-N = 4,4-dimethyl-2,2-bipyridine(dmb,Ru 1),2,2 bipyridine(bpy,Ru 2),and Cl-Ph-βC(Cl-phenyl-9H-pyrido[3,4-b]indole)were synth

【作者】

：

Yuan-yuan Deng Jie Wang Lan-mei Chen Jin-can Chen

【机构】

：

Guangdong Key Laboratory for Research and Development of Natural Drugs,School of Pharmacy,Guangdong

【出处】

：

第十一届全国化学生物学学术会议

【发表日期】

：

2019年3期

【关键词】

：

β-carboline ruthenium(Ⅱ) complexes ROS mitochondrial membrane potential DNA dama

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

基于ESI-MS/MS和ESI-IT-TOF-MS/MS方法的甾体激素质谱裂解规律研究

甾体激素是一类广泛应用于临床上各种相关疾病的诊断和治疗的具有环戊烷骈多氢菲母核的脂质化合物[1]。其中的糖皮质激素能够通过内分泌系统调控糖、脂肪、和蛋白质三大物质代谢,具有抗炎、抗休克、抗毒素、免疫抑制作用；性激素具有促进性器官成熟、副性征发育及维持性功能、促进家畜繁殖生长及植物生长[1,2]的作用。

会议

甾体激素质谱裂解规律

Fabrication of red blood cell membrane-camouflaged Cu2-xSe nanoparticles for second near-infrared re

Rarely reported but aroused widespread concern in the second near-infrared(NIR-II)region(1000-1700 nm)opens up many new wonderful avenues of phototherapy [1].

会议

Nanoparticlesphotothermal therapyphotodynamic therapy

A lysosome-targeted and two-photon excitable iridium(Ⅲ)complex for bimodal visualization of endogeno

Nitric oxide(NO)is a fundamental signaling molecule that shows complex effects on the catabolic autophagy process,which is closely linked with lvsosomal function.

会议

Iridium complexNitric OxideTwo-photonLifetime ImagingLysosomeZebrafish

bodipy修饰钌多吡啶配合物的光动力治疗效果研究

光动力治疗是通过合适波长集中辐射肿瘤部位,无毒的光敏剂产生细胞毒性物质如活性氧,达到对周围正常细胞几乎无害的优异的微创肿瘤治疗方式。金属钌配合物拥有生物相容性好、配体易修饰,单线态氧量子产率高和发光寿命长等特点,其用于细胞器靶向的单/双光子动力治疗本课题组已进行较多研究[1,2]。

会议

钌多吡啶配合物bodipy光动力治疗

Nucleus DNA targeted cyclometalated Ru(Ⅱ)complexes as low-toxicity anticancer agents to inhibit lung

Two new cyclometalated Ru(Ⅱ)complexes containing isoquinoline ligand,[Ru(bpy)2(1-Ph-IQ)](PF6),(bpy = 2,2-bipyridine; 1-Ph-IQ = 1-phenylisoquinoline; Ru1)and [Ru(phen)2(1-Ph-IQ)](PF6)(phen = 1,10-phena

会议

cyclometalated Ru(Ⅱ) complexesapoptosisDNA damagein vivo toxicity

Rapid kinase decaging coupled with phosphotyrosine proteomics enables cellular signal pulse-chase

Tyrosine phosphorylation(p-Tyr)is a canonical form of cellular signaling transduction,deregulation of which can drive cancer germination.

会议

Kinase decagingtyrosine phosphoproteomicssecond-scale temporal resolution

A new type of cyclodextrin based,specifically modified fluorescence gold nanoclusters as carrierrs f

Multifunction drug delivery and combined multimodal therapy strategies are very promising in tumor diagnostic and theranostic application.

会议

Fluorescencetargetingtumor treatmentgold nanomaterials

多臂G-四链体探针的制备及性质研究

富含鸟嘌呤碱基(Guanine)的核酸序列在碱金属(如K+或Na+)存在下，通过G 碱基间Hoogsteen 氢键作用可堆积形成非传统四链体螺旋结构，称为G-四链体(G4)结构[1]。

会议

G4 DNA肿瘤相关荧光探针HRAS

Rational Design of Two-photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Live

Monoamine oxidases(MAOs)are important mammalian enzymes that catalyze the transformation of various neurotransmitters including serotonin,dopamine,phenethylamine,and others.

会议

monoamine oxidase AMPTPtwo photon fluorogenic probesmolecular docking

共轭寡聚物的细胞内自组装克服细胞耐药

目前，癌症仍是全世界最难以治愈的疾病之一，临床上通过化学疗法可以一定程度上控制病情，但是患者时常出现严重复发，同时还伴随着药物耐药性的产生，因此肿瘤细胞的多药耐药性是世界上最为复杂和最难克服的难题之一。

会议

共轭寡聚物细胞内自组装交联抗癌

Cyclometalated Ru(Ⅱ)complexes [Ru(L)2(Cl-Ph-βC)]+(L=bpy,dmb)as potent anticancer agents induce apopt

与本文相关的学术论文