【摘 要】
：
Aim To study the antihypertensive effect of total flavonoids of Cydonia oblonga Mill.in spontaneously hypertensive rats, then preliminarily investigate the mechanism of action based on antiinflammator
【机 构】
：
Dept of Pharmacology,Xinjiang Medical University,Urumqi 830011,China
论文部分内容阅读
Aim To study the antihypertensive effect of total flavonoids of Cydonia oblonga Mill.in spontaneously hypertensive rats, then preliminarily investigate the mechanism of action based on antiinflammatory function.Methods Total flavonoids of COM (COMF) were separated and purified by the optimal process, SHR were divided into 6 groups as SHR control group (SHR), captopril group (CAP, 25rg · kg1 · d1), Eucommia ulmoides Oliver group (EUO, 30 mg · kg1 · d1), low (COMFL, 40 mg · kg1 · d1), middle (COMFM, 80 mg ·kg1 · d1) and high dose (COMFH, 160 mg · kg1 · d1) of COMF groups.8 WistarKyoto (WKY) rats were given distilled water instead as control.The drugs were given by intragastric administration for 16 weeks, then the levels of IL1β, IL6, IL10, TNFα and CRP in serum were tested.Results Compared with WKY group, the levels of IL1β, IL6, TNFα and CRP were increased and IL10 was decreased; Compared with SHR group, the levels of IL1 β, IL6, TNFc and CRP were decreased in COMF groups (P <0.01 or P <0.05), while IL10 was increased a little but without any significant difference (P < 0.05).Conclusion Total flavonoids of Cydonia oblonga Mill.showed the antihypertensive activity in spontaneously hypertensive rats and the mechanism was related to the function of antiinflammatory.
其他文献
Aim Middle cerebral artery occlusion/reperfusion (MCAO/R) is a widely used animal model for cerebral ischemiareperfusion injury, which causes great harm to human health.Salvianolic acid A (SalA) from
Aim Magnesium lithospermate B (MLB) is the most abundant hydrophilic active component of Salvia miltiorrhiza Radix, a traditional Chinese herbal medicine mainly used to treat cardiovascular diseases.S
Aim Endoplasmic reticulum (ER) stress is increasingly recognized as an important contributor to the pathophysiology of many diseases, and therapeutic interventions that target ER stress response emerg
Aim In diabetic patients, mefformin appears to provide cardiovascular protection that cannot be attributed only to its antihyperglycemic effects.Metformin is also known as the AMPactivated protein kin
Ain Baroreflex dysfunction is associated with a higher rate of sudden death after myocardial infarction(MI).Ketanserin enhances baroreflex function in rats.The present work was designed to examine whe
Aim The expression of α3 subunit of nicotinic acetylcholine receptor (α3nAChR) has been demonstrated in aorta, adipocyte and macrophage.The objective of the present study was to verify the regulatory
Aim Salidroside (SAL) is a phenylpropanoid glycoside isolated from the medicinal plant Rhodiola rosea.A recent study has reported that SAL can efficiently decrease atherosclerotic plaque formation in
Aim Stable microtubules (MTs) is involved the mechanism of diabetic cardiomyopathy (DCM), which is induced by acetylation of αtubulin.The present study investigated whether SIRT2, a deacetylase, regul
目的 探讨达比加群酯致消化道出血的风险因素。方法 通过MEDLINE数据库收集"2010年至2015"有关达比加群酯用于预防房颤患者脑卒中时并发消化道出血个案，结合文献检索，进行综合分析与汇总。结果 共检索有关达比加群酯用于预防房颤患者脑卒中时并发消化道出血文献165篇，个案病例50余例，其中13例详细记载患者性别、年龄、病史(原患疾病)、用药史(联合用药史)、临床表现、相关临床指标、治疗措施及效
Aim To study the activity and mechanism of inhibition of myocardial hypertrophy of total flavonoids of Cydonia oblonga Mill.in spontaneously hypertensive rats.Methods Total flavonoids of COM (COMF) we