【摘 要】
：
Background: Matrix metalloproteinases (MMPs) are directly implicated in degradation of extracellular matrix.Multiple studies have shown that MMPs and their inhibitors are involved in various pathologi
【机 构】
：
1st Internal department-Cardiological clinic St.Anna University Hospital Czech republic
【出 处】
：
BITs 2rd Annual World Cancer Congress of Cardiology-2010(201
论文部分内容阅读
Background: Matrix metalloproteinases (MMPs) are directly implicated in degradation of extracellular matrix.Multiple studies have shown that MMPs and their inhibitors are involved in various pathological processes as well as acute graft rejection.This study analyzed serum concentrations of MMP-2,9 and tissue inhibitor of metalloproteinases (TIMP)-1 in heart transplant (HTx) patients with different result of endomyocardial biopsy (EMB).Methods: Generally 37 endomyocardial biopsy samples and serum samples of MMP-2,9, TIMP-1 were obtained from 30 HTx recipients (group A: grade 0+IA, n=27; group B:grade IB, n=10).Mean patient age was comparable in both group (group A: 50.6± 8.4 vs.group B: 53.2± 3.3 years).Myocardial biopsies, serum samples and echocardiography were done from 4 to 6 months after Htx with standart immunosuppressive therapy.Serum levels of MMP-2,9 and TIMP-1 were assayed by ELISA.EMB were evaluated according to ISHLT guidelines.Results: Comparable serum concentrations ofMMP-2,9, TIMP-1 and echocardiography parameters were observed in both group.Conclusions: Our results indicate, that there isnt evidence for changes of concentrations of MMP-2,9 and TIMP-1 in heart transplant recipients with mild diffuse acute cellular rejection versus without rejection.Study limitation was absence of higher grade of graft rejection.
其他文献
Ischemic heart disease is expected to become the leading cause of death by the end of year 2010 and is currently the main cause of acute myocardial infarction (AMI).Despite significant progress in tre
ST-segment elevation myocardial infarction (STEMI) is caused by acute coronary occlusion due to rupture of vulnerable plaque or superficial erosion of a proteoglycan-rich plaque.Although, primary perc
Cardiovascular disease (CVD), and in particular coronary artery disease (CAD) is the leading cause of mortality both in men and women.In Europe, more than half of all females deaths are caused by CVD,
Introduction) Quadricuspid aortic valve is very rare.There are few reports of aortic valve plasty for quadricuspid aortic valves.In contrast, bicuspid aortic valve is relatively common congenital card
Aortic valve stenosis in young patients poses a unique set of challenges in the management.The etiology of the disease varies from congenital hypoplasia of the valve, multiple level left ventricular o
Objective outcome measures, e.g.survival, mortality, morbidity, complication rate, symptom recurrence, and need for re-interventions, have long been used as benchmarks for successful cardiac surgery.A
The chronic valvular heart disease (VHD) is the commonest cause of acquired heart disease in children of 5-15 years age group.This is attributed to the acute rheumatic fever (ARF) which is immunologic
Rheumatic heart valve disease (RHD) has become rare.We investigated the results of a standardized minimal invasive approach for RHD consisting in a right antero-lateral mini-thoracotomy (RMT), focusin
The presentation follows the most recent classification of pulmonary hypertension (2008 4th World Symposium on PH, Dana Point, California) and discusses a specific category of pulmonary vasculopathy,
Pulmonary hypertension (PH) leads to progressive increase of pulmonary vascular resistance, heart failure and death.Pulmonary arterial hypertension (PAH) is a subset of PH affecting small pulmonary ar