【摘 要】
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Objective The human androgen receptor (AR) gene contains 2 polymorphic trinucleotide (CAG and GGN) repeats sequence in exon 1, which can transcript into Glutamine (Gln) and Glycine (Gly) respectively.
【机 构】
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First Affiliated Hospital of Nanjing Medical University
【出 处】
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中华医学会第七次全国生殖医学学术会议
论文部分内容阅读
Objective The human androgen receptor (AR) gene contains 2 polymorphic trinucleotide (CAG and GGN) repeats sequence in exon 1, which can transcript into Glutamine (Gln) and Glycine (Gly) respectively.The number of CAG and GGN repeats may confer differential receptor activity, and specific ranges of variants have been correlated with androgen-sensitive disease processes.Polycystic ovary syndrome (PCOS) is a female condition characterized by infertility, oligomenorrhea and androgen excess, many features of which are effectedthrough the AR.
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