【摘 要】
：
The aim of our study was to investigate the antitumour effects of xanthoceraside, a new triterpenoid saponin, in four kinds of cancer cells in vitro and the
【机 构】
：
Shenyang Pharmaceutical University China
【出 处】
：
BITs 3rd Annual World Cancer Congress-2012(2012第五届世界癌症大会)
论文部分内容阅读
The aim of our study was to investigate the antitumour effects of xanthoceraside, a new triterpenoid saponin, in four kinds of cancer cells in vitro and the mechanism of the induced cytotoxicity on A375.S2 cells by apoptosis.The results indicate that xanthoceraside significantly inhibited the proliferation of four kinds of cancer cells in a dose-dependent manner.Xanthoceraside also induces apoptosis in A375.S2 cells.The marked morphological changes including condensed chromatin, nuclear fragmentation and apoptotic bodies;and DNA ladder in agarose gel were observed.The apoptotic mechanism was that xanthoceraside treatment regulated Bad, Bcl-xL and Bcl-2 proteins, leading to mitochondrial depolarization, cytochrome release, AIF, Apaf-1 and easpase activation.Moreover, we confirmed that the Raf-MEK-ERK/JNK/p38 and PI3K-AKT-CREB pathway were involved in xanthoceraside-induced apoptosis.In conclusion, these results indicate that xanthoceraside induces apoptosis via a mitochondrial, Raf-MEK-ERK/JNK /p38 and PI3K-AKT-CREB pathway.
其他文献
宁波市交通局升船过堰机站广大职工在毛主席的革命路线指引下,发扬继续革命的精神,群策群力,自力更生,大搞技术革新,于1972年12月实现了升船机自动控制惯性过点。
Under th
综合营养专家的意见,我国饮食习俗中主要存在以下九大缺点,需要引起大家注意:1.吃得过咸。据统计,全国人均吃盐量为每天10克以上,其中以东北人最高,达18克。而世界卫生组织建
Neuroblastoma is an embryonic malignancy arising from neuroblasts.The mechanisms that regulate the origination of neuroblastoma are still not very clear.In
据最新一期英国《新科学家》杂志报道,美国一项研究显示,父母在生活中如果有过多的焦虑,会使他们的孩子更容易出现健康问题。美国罗切斯特大学研究
According to the latest
一颗糖,微不足道,可当它成为师生心与心之间的桥梁,成为学生生命中的甜蜜源泉时,我才真正意识到它的分量.rn永续温馨师生情rn临近春节,我收到了曾经教过的一个学生的祝福短信
安徽省安庆大件码头,总投资300万元,土石方和混凝土的工程量约30万立方米,于今年5月提前三个月完成了主体工程。大件码头工程仅用七小月时间完成主体工程,主要原因是工程处
我出生在一个崇尚手机造型时尚、影音娱乐功能风行的时代,作为2006年天时达重点推荐的机型,我具备外观轻薄、影音娱乐功能强大、价格便宜等特点,我一一就是天时达TS816。
I
Activating transcription factor 1 (ATF1) overexpression correlates with tumor progression in multiple tumors, and yet the involvement of ATF1 in gastrointes
中华人民共和国成立三十五年了。三十五年来,我们的伟大祖国发生了翻天覆地的变化,公路面貌也焕然一新。翻开新出版的全国公路图,我们可以看到,一条条公路线纵横交错,把祖国
花木、果树枝条扦插常用生根激素如奈乙酸等处理,以提高其成活率。但是生根激素价格既高,又不易买到。共实,有很多物质具有促进植物生长的功能,也同样能促进插条生根。它们