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Objectives Epidemiologic studies have been performed to explore the relationship between MCP-1 polymorphism and ischaemic heart disease (IHD) and ischaemic stroke (IS).But, the results are not consistent.Because of the poor effect of single study, we performed a systematic review and meta-analysis Methods A comprehensive search was carried out from PubMed, Foreign Medical Journal Service (FMJS), China National Knowledge Infrastructure (CNKI) and Wanfang Data.