Novel Histone Demethylase LSD1 Inhibitors Selectively Targets Cancer Cells with Pluripotent Stem Cel

来源 :2013第六届世界癌症大会 | 被引量 : 0次 | 上传用户：quyeliang

【摘要】

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【作者】

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Tao Ye

【机构】

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Hong Kong Polytechnic University, Peking University Shenzhen Graduate School Hong Kong, China

【出处】

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2013第六届世界癌症大会

【发表日期】

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2013年12期

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　　Histone modification determines epigenetic patterns ofgene expression with methylation of histone H3 at lysine 4 (H3K4) often associated with active promoters.LSD1/KDM1 is a histone demethylase that suppresses gene expression by converting dimethylated H3K4 to mono-and unmethylated H3K4.LSD1 is essential for metazoan development, but its pathophysiologic functions in cancer remain mainly uncharacterized.In this study, we developed specific bioactive small inhibitors of LSD1 that enhance H3K4 methylation and derepress epigenetically suppressed genes in vivo.

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Novel Histone Demethylase LSD1 Inhibitors Selectively Targets Cancer Cells with Pluripotent Stem Cel

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