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Diterpenoids,a largest group of natural products,are the focus of natural drug discovery due to their structural diversity and wide range of biological activities.Recently,as part of our continuing efforts to discover the structurally unique and biologically significant diterpenoids from natural resources,we undertook chemical analyses of three soft corals and eight medicinal plants,which led to the isolation of about 100 diterpenoids,including 46 new diterpenoids and an unusual skeleton.