Design,Synthesis and Biological Evaluation of Thiazolopyrimidin-7-One Derivatives as novel PAM of nA

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户:dlfb
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  Alzheimers disease(AD)is a fatal neurodegenerative disease with the deterioration of cognitive and memory functions.Homologous α7 nicotinic acetylcholine receptors have high calcium permeability,which regulate the calcium activation and the release of neurotransmitter acetylcholine[1].
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