Supramolecular Prodrug Based on the Host-guest Interaction for Intracellular Drug Delivery

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  Cancer has emerged as one of the leading causes to peoples death which motivates the extensive research interests.With enhanced therapeutic efficacy and reduced side effects,the last few decades have witnessed a rapid development in utilizing polymeric prodrug micelles for drug delivery and cancer therapy research.However,problems still exist such as complicated synthetic procedures,low drug content.In recent years,host-guest interactions have been widely used as driving force to prepare biomaterials.Thus,we envision that whether we can prepare supramolecular prodrug micelles based on different kinds of macrocyclic host molecules.Herein we provide different possibilities using macrocyclic host molecules for drug delivery.
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