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To meet the increasing demands of specific pathogen free (SPF) minipigs in biomedical researches, we established a SPF Chinese Wuzhishan minipigs (WZSP) colony by hysterectomy.The background data of the SPF WZSP colony were collected and further compared to those of conventional (CV) WZSP.Results showed that piglet survival rates, growth performance, and reproductive performance of SPF WZSP were similar to CV WZSP.Some hematology and blood biochemistry parameters showed significant differences between SPF and CV WZSP.Eighteen kinds of pathogens were identified to be free in the SPF colony by repeated pathogen detections.In conclusion, we established a satisfied SPF WZSP colony maintaining original characteristics and proving to be a suitable animal model.