【摘 要】
：
3-Aminopyrrolidin-2-one derivatives are important ones of heterocyclic compounds with a wide array of bioactivities.Trapping ammonium ylides[1] in situ generated from diazo compound 1 and aromatic ami
【机 构】
：
Institute of Drug Discovery and Development,East China Normal University,No.3663,North Zhongshan Roa
【出 处】
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The 24th International Society of Heterocyclic Chemistry Con
论文部分内容阅读
3-Aminopyrrolidin-2-one derivatives are important ones of heterocyclic compounds with a wide array of bioactivities.Trapping ammonium ylides[1] in situ generated from diazo compound 1 and aromatic amine 2 in the presence of Rh(Ⅰ) complex catalyst[2] by quinine-activated β-nitroacrylates 3 and after reductive cyclization provides 3-aminopyrrolidin-2-one derivatives in economical step fashion with moderate to high diastereoselectivity and high yields.
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