Synergetic Work of Domain Ⅱ and Domain Ⅳ Underlie Persistent Current in Nav1.3 As Revealed by a Tara

来源 :10th IST Asia Pacific Congress on Animal , Plant and Microbi | 被引量 : 0次 | 上传用户：shiyiliang

【摘要】

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【作者】

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Cheng Tang Xi Zhou Yunxiao Zhang Ying Huang Changxin Zhang Bo Chen Zhonghua Liu Songping Liang

【机构】

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College of life science,Hunan Normal University,Changsha 410081,China

【出处】

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10th IST Asia Pacific Congress on Animal , Plant and Microbi

【发表日期】

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2014年5期

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Persistent current (INaP) in voltage-gated sodium channels (Nav) enhances neuron excitability by causing prolonged depolarization of membranes and thus is considered as a potential mechanism for epilepsy.Several mutations in Nav1.3 were found to enhance INaP,but mechanism underlying INaP is still to be explored.

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Synergetic Work of Domain Ⅱ and Domain Ⅳ Underlie Persistent Current in Nav1.3 As Revealed by a Tara

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