【摘 要】
:
INTRODUCTION: Snakebites by Bothrops jararacussu (BJU) induces intense local tissue damage and there is no effective therapy against myotoxicity.Phospholipases A2 toxins are enzymes present in the ven
【机 构】
:
Laboratório de Farmacologia das Toxinas / UFRJ;Instituto Vital Brazil,Niterói-RJ,Brazil
【出 处】
:
10th IST Asia Pacific Congress on Animal , Plant and Microbi
论文部分内容阅读
INTRODUCTION: Snakebites by Bothrops jararacussu (BJU) induces intense local tissue damage and there is no effective therapy against myotoxicity.Phospholipases A2 toxins are enzymes present in the venom which are responsible for a wide range of activities.We assessed the ability of Fucosylated Chondroitin Sulfate (fucCS) and its carboxi-reduced (fucCS-CR) and defucosylated (defucCS) derivatives to antagonize the muscle damage induced by BJU toxins,named Bothropstoxin-I(BthTX-Ⅰ) and Bothropstoxin-Ⅱ (BthTX-Ⅱ).
其他文献
Recently,large blooming of jellyfish species has been more frequent and widespread in the oceans of Korea,China,and Japan.Simultaneously,the victims of poisonous jellyfish stinging have also increased
In vitro evolution technologies have been applied to improve biophysical properties,or even to generate novel functions of proteins.It is possible to develop protein scaffolds which can be potentially
Stomolophus meleagris,a large jellyfish with strong toxicity,often bloomed in late summer to early autumn from the Bohai Sea to the Yellow Sea,and in the South China Sea in recent year.Every year,thou
The small,highly structured peptides in marine cone snail venom target a variety of membrane receptors and ion channels.Several disulfide-bonded peptides (conotoxins) inhibit nicotinic acetylcholine r
Several peptide toxins,which have different targets,can be found in the venom of arthropods,what makes them a rich source of bioactive molecules.Some of these peptides can be potentially used as drug
Toxin peptides can effectively suppress bacterial growth and blocking channel conductance.Toxins can either be drugs for channels or receptors,or act as chemical probes for cellular function studies o
Cone snails (genus Conus) are marine species that evolved as specialized predators by developing the most sophisticated peptide chemistry and neuropharmacology in their venom.These venom peptides,call
A filamentous marine cyanobacteria Moorea producens (formerly classified as Lyngbya majuscula) can cause human skin irritation (seaweed dermatitis) known as "swimmers itch".The causative agents of "sw
NKCT1 was purified from Naja Kaouthia snake venom.Gold nanoparticle was prepared by NaBH4 reduction method and conjugated with NKCT1 by using Polyethylene glycol.Arthritis was induced by Freunds compl
Recently reported peptide toxins mambalgins are a novel class of snake venom components that act as pain reducer through the inhibition of acid-sensing ion channels (ASICs).With the synthesized three-