【摘 要】
：
INTRODUCTION: Snakebites by Bothrops jararacussu (BJU) induces intense local tissue damage and there is no effective therapy against myotoxicity.Phospholipases A2 toxins are enzymes present in the ven
【机 构】
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Laboratório de Farmacologia das Toxinas / UFRJ;Instituto Vital Brazil,Niterói-RJ,Brazil
【出 处】
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10th IST Asia Pacific Congress on Animal , Plant and Microbi
论文部分内容阅读
INTRODUCTION: Snakebites by Bothrops jararacussu (BJU) induces intense local tissue damage and there is no effective therapy against myotoxicity.Phospholipases A2 toxins are enzymes present in the venom which are responsible for a wide range of activities.We assessed the ability of Fucosylated Chondroitin Sulfate (fucCS) and its carboxi-reduced (fucCS-CR) and defucosylated (defucCS) derivatives to antagonize the muscle damage induced by BJU toxins,named Bothropstoxin-I(BthTX-Ⅰ) and Bothropstoxin-Ⅱ (BthTX-Ⅱ).
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