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To improve the intracellular drug release and anticancer efficacy in cancer therapy, in the present study, a pH and redox dual-sensitive biodegradable micellar system was developed for paclitaxel (PTX) delivery based on the self-assembly of D-α-tocopheryl polyethylene glycol 1000-SS-poly (β-amino ester) (TPGS-SS-PBAE) copolymer.TPGS-SS-PBAE copolymer was first synthesized via Michael addition polymerization of diacrylate and piperazine in the presence of TPGS-SS-diacrylate macromonomer.