【摘 要】
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This study was designed to assess the safety, tolerability, pharmacokinetics and preliminary efficacy of BC-819 administered intratumorally in subjects with unresectable, locally advanced pancreatic c
【机 构】
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Head, Division of Surgical Oncology; Associate Professor of Surgery University of Maryland School of
论文部分内容阅读
This study was designed to assess the safety, tolerability, pharmacokinetics and preliminary efficacy of BC-819 administered intratumorally in subjects with unresectable, locally advanced pancreatic cancer.BC-819 is a DNA plasmid that targets the expression of diphtheria toxin gene under the control of H19 regulatory sequences.H19 RNA is present at high levels in human cancer tissues, while existing at a nearly undetectable level in the surrounding normal tissue.
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