A series of novel 6-substituted diarylpyridine derivatives targeting the entrance channel of the NNRTI binding pocket(NNIBP)of HIV-1 RT was designed through a molecular hybridization strategy.
Forty-two compounds(series 8,9 and 10)incorporated with diacylated piperazine have been synthesized and evaluated as novel Bcr-Abl inhibitors based on six-atom linker.
Here we report a facile approach to synthesize highly optically active oxindole-type analogues with both high yield and enantioselectivity in a single step.