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The human transcriptome comprises not only large numbers of protein-coding messenger RNA(mRNAs) but also a large set of non-protein coding transcripts that have structural，regulatory or unknown functions. Although studies of small non-coding RNAs (18 to 200 nucleotides (nt)) have dominated the field of RNA biology in recent years，a surprisingly wide arcay of cellular functions has also been associated with long non-coding RNAs (1ncRNAs).IncRNA-HEIH is an oncogenic INcRNA that promotes tumor progression and leads us to propose that 1ncRNAs may serve as key regulatory hubs in HCC progression.