【摘 要】
：
Cancer remains a leading cause of death with current therapeutic methods. Novel therapies are therefore in urgent needs. One potential method is to use bacteria
【机 构】
：
TheUniversityofHongKong
【出 处】
：
Workshop on Mathematical and Physical Methods for Biological
论文部分内容阅读
Cancer remains a leading cause of death with current therapeutic methods. Novel therapies are therefore in urgent needs. One potential method is to use bacteria as cancer therapeutic agent. Since bacteria can sense their environment, distinguish between cell types, synthesize and deliver drugs into cancer cells, attempts are made to program bacteria to attack tumors. Current advances in synthetic biology technology offer great opportunities in refining this approach. In this talk, Dr. Huang will discuss a stepwise approach to program bacterial strains that are able to detect tumor microenvironment, effective in killing cancer cells and safe to normal tissues. He will present data to show that the engineered bacteria, equipped with a newly designed system that is capable to express and deliver therapeutic proteins and RNAs, have potent therapeutic effects on the primary tumors in both immunocompromised and immunocompetent mice. More importantly, metastasis was greatly reduced when mice were treated with the engineered bacteria. However, the mechanisms underlying cancer killing is not completely understood. Possible mechanisms of killing will be discussed.
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