Methylation of CTNNA1 promoter frequent but not an adverse prognostic factor in acute myeloid leukem

来源 :The 35th World Congress of the International Society of Hema | 被引量 : 0次 | 上传用户:Whoafraidwh0
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Objective The reduced expression of CTNNA1 gene,a putative tumor suppressor gene,has been found in several cancers including acute myeloid leukemia (AML).CTNNA1 expression is regulated by methylation and histone deacetylation.However,the clinical significance of CTNNA1 methylation in AML is rarely known.
其他文献
Object Vitamin D is a steroid hormone that plays an important role in varies physical functions,such as calcium metabolism and bone health,with increasingly recognized associations with chronic diseas
会议
研究目的(Objective) 落實「感染管制」議題,一向是衛生署醫療品質及病人安全每年必要執行目標,建立有效手術室器材的管理與滅菌品質的監測過程,即為院內感染防禦機制的重要角色之一。為此,透過資訊系統的整合與運用,將手術室器械單包與包盤一系列導入滅菌自動化管理作業,定期定點追蹤滅菌器材使用與保存,發現滅菌過程異常的探討與分析,強化手術室器械管理與感染管制。研究方法(Methods) 結合醫院資訊
目的 探讨综合护理绩效考核评价方法在优质护理服务中的应用及效果观察.方法 2014 年8 月-2015 年5 月期间对我院病区268名护士施行新型综合护理绩效管理方法,另选择2013 年10 月-2014年7 月期间227 名护士实施的原有单一护理绩效办法作为对照,比较两种绩效方法使用前后对全院护理质量、患者满意度及护士满意度的影响.结果 综合绩效方法显著提升了护士满意度,调动了护士工作积极性,护
目的 探讨心电图对PICC 尖端最佳位置定位及置管并发症影响.方法 将120 例行PICC 置管的成年肿瘤患者,按随机数字表分为对照组和实验组,每组各60 例.对照组在彩色多普勒超声机引导下使用改良的塞丁格技术进行PICC 置管.实验组在对照组的基础上加用心电图指导PICC 尖端定位.置管结束后两组均拍摄胸部立位平片确定导管尖端位置,比较二者定位结果.并对两组置管患者进行为期1 个月的随访观察,比
2013 年《美国医学会杂志》上的一则研究披露:中国成年人群的糖尿病总体发病率估计为11.6%;男性为12.1%,女性为11.0%,新检测到的糖尿病发病率估计为8.1%,而前驱糖尿病的患病率大约为50%[1].目前世界卫生组织的有关资料表明:糖尿病的患病率、致残率和病死率以及对身体的危害程度,已居慢性非传染性疾病的第3位.世界卫生组织预测:到2030 年糖尿病数量将增加到3.66 亿,新增的患者将
Objective To explore the clinical character and prognosis of Hepatitis E virus infection in patients with hematological malignancies.Methods From May 2011 to May 2013,patients of acute leukemia and ly
会议
Purpose Minimal residual disease (MRD) detected by multiparametric flow cytometry is an important method for predicting relapse.According to the dynamic changes of MRD,through the first clinical treat
会议
Purpose To establish a method for detecting minimal residual disease (MRD) by eight color flow cytometry which is stable,repeatable and accurate quantitation.Method According to the ratio of 10%,1%,0.
会议
Backgroud Familial hemophagocytic lymphohistocytosis (FHL) is a genetic disorder oflymphocyte cytotoxicity that usually presents in the first two years of life and has a poor prognosisunless treated b
会议
Jak2 is a nonreceptor tyrosine kinase belonging to the Janus (Jak) family of tyrosine kinases.The JAK2 V617F mutation renders the kinase constitutively active and leads to the human myeloproliferative
会议