【摘 要】
：
Head and neck squamous cell carcinoma (HNSCC) arises from stratified epithelia of the oral cavity, pharynx, larynx, and represents the 6th most common cance
【机 构】
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University of Colorado USA
论文部分内容阅读
Head and neck squamous cell carcinoma (HNSCC) arises from stratified epithelia of the oral cavity, pharynx, larynx, and represents the 6th most common cancer worldwide.Compared to the more common cancer types, such as breast and prostate cancers, the 5-year survival rate of HNSCC patients has not been significantly improved during the past three decades.This is mainly due to lack of understanding of the molecular mechanisms of HNSCC development and effective therapeutic approaches.Activation of PI3-kinase pathway, either by activation of the oncogenes in this pathway, such as PIK3CA, or AKT, or by loss of the tumor suppressor PTEN, is an extremely common event in human malignancies including HNSCC, and targeting PI3-kinase pathway represents one of the most promising therapies for human cancers.
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