【摘 要】
：
Aims To evaluate and compare the effect of total body irradiation (TBI) with busulfan/cyclophosphamide (BU/CY) as conditioning regimen on the development of
论文部分内容阅读
Aims To evaluate and compare the effect of total body irradiation (TBI) with busulfan/cyclophosphamide (BU/CY) as conditioning regimen on the development of hepatic veno-occlusive disease (HVOD) occurring after hematopoietic stem cell transplantation (HSCT).Methods Mice received either TBI (7.5 Gy with rate at 0.67 Gy/min) (n=20) or BU/CY (80 and 200mg/kg/d)(7-4 days for BU and 3-2 days for CY before transplantation) (n=20) followed by HSCT.Liver and whole blood collected 15 days post HSCT were used for the analysis of liver pathology changes by H&E, immunohistochemical and Mason staining, ultrastructure by transmission electron microscope, function (level of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP)) by Bio-Chemical Analyzer, peripheral white blood cell (PWBC) count by blood cell counter, reticulocytes and platelet activation by flow cytometry.
其他文献
目的 移植物抗宿主病(GVHD)是HLA单倍型造血干细胞移植的主要并发症。目前,GVHD的预防仍然采用以环孢素为基础的多药联合策略,预防效果并不满意。体内外研究发现他克莫司
目的 了解WMIPSS中、高危淋巴浆细胞淋巴瘤/华氏巨球蛋白血症(LPL/WM)患者的临床特征，探讨这部分患者的治疗及生存情况.方法 回顾性分析2001.01至2014.06于我院就诊的48例
目的 慢性移植物抗宿主病(cGVHD)是HLA单倍型造血干细胞移植(haplo-HSCT)主要并发症，发生率在50％-60％，严重影响移植患者生活质量，甚至继发感染导致患者死亡。体内外研究发现间
Objective Previously, we demonstrated the importance ofT-cell immune response cDNA 7 (TIRC7) in acute i mmune thrombocytopenia (ITP).As the downstream molec
Objective T-cell immune response cDNA 7(TIRC7) has been identified and demonstrated to be essential in T cell activation.However, the role of TIRC7 in acute
目的 探讨在小鼠异基因骨髓移植(bone marrow transplantation,BMT)中,联合输注内皮祖细胞(Endothelial progenitor cells,EPCs),在修复血管niche的同时,对骨髓细胞的影
Aims To evaluate the role of RUNX3 in the pathogenesis of ITP.Methods 47 active ITP patients, 18 ITP with remission and 26 age and gender matched healthy co
目的 研究骨髓移植预处理对肝脏损伤及与血小板活化的关系。方法 实验分组将BABL/c小鼠随机分为3组,即对照组：正常小鼠、致死量照射组；实验组：骨髓移植组。照射后观察小鼠生
目的 分析左旋门冬酰胺酶与培门冬酶对成人急性淋巴细胞白血病患者凝血功能的影响及其相关因素。方法 回顾性分析2010年1月至2015年1月共153位急性淋巴细胞白血病患者，其