Aberrant hypermethylation of CTNNA1 gene is associated with higher IPSS risk in patients with myelod

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Objective CTNNA1 gene is a putative tumor suppressor for its roles in inhibiting proliferation and promoting apoptosis.Aberrant expression of CTNNA1 is regulated by epigenetic mechanisms including both promoter methylation and histone deacetylation in hematopoietic malignancies.
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