Centrifugal microfluidics enables efficient miniaturization, integration, parallelization and automation of biochemical assays especially for Point-of-Care applications.This talk will demonstrate fully integrated sample-to-answer genotyping assays from whole blood which enables rapid diagnostics of infectious diseases.The assays are implemented on a LabDisk which is fabricated by micro-thermoforming from thin polymer films and are performed within 3 hours on a small and lightweight instrument.Novel and advanced centrifugal unit operations will be presented such as integrated pneumatic pumping as well as the merging of droplet microfluidics with centrifugal microfluidics for implementation of fast digital amplification assays that are promising to perform fully automated tests within less than 1 hour.Finally, challenges and solutions for the scale-up of manufacturing the polymer LabDisk by microthermoforming will be discussed.