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目的 NVP-BKM120(BKM120)isabrandnewinhibitorofpan-classIphosphatidylinositol-3kinase(PI3K)andhasbeentestedinclinicaltrialsasananticanceragent.Inthisstudy,wedeterminedwhetherBKM120inducesautophagyanditsimpactonBKM120sgrowth-inhibitoryactivitysincethePI3K/Akt/mTORsignalingisknowntonegativelyregulateautophagy.