Emerging and reemerging human viral pathogens pose great public health concerns since therapeutics against these viruses are limited.Thus there is an urgent need to develop novel drugs which can block infection of either a specific virus or a number of viruses.Viral entry is thought to be an ideal target for potential therapeutic prevention.One of the challenges of developing antivirals is that most of these viruses are highly pathogenic, and therefore require high biosafety level containment (BSL-3 or-4).My group has adopted a comparative high throughput screening (HTS) protocol to identify inhibitors for different enveloped viruses using an human immunodeficiency virus-1 (HIV-1)-based pseudotyping platform with alleviated safety concerns.In this presentation, I will describe our recent work on identifying antiviral inhibitors from natural products (plants), using the discovery of anti-HIV-1 inhibitors as an example.We believe that our approach is applicable to antiviral drug discovery from Chinese Medicinal products.