【摘 要】
：
Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline.The current study focused on the expression of PADI4 in various subtypes of ovary cancers,and this study investigat
【机 构】
：
Research Center For Medicinal Biotechnology, Shandong Academy of Medicinal Sciences, Key Laboratory
【出 处】
：
泛环渤海地区(七省二市)生物化学与分子生物学会2010年学术交流会
论文部分内容阅读
Peptidylarginine deiminase type 4 (PADI4) converts arginine residues into citrulline.The current study focused on the expression of PADI4 in various subtypes of ovary cancers,and this study investigated the effects of estrogen on PADI4 expression in SKOV-3 cells that originated from ovary tumors.We utilized immunohistochemistry,real-time PCR and western blotting to analyze the expression of PAD14 in the tumor tissues and in the cell line that were cultured with estrodial-17 PADI4 was detected in serious cystadenocarcinoma (n=39,positivity=100%),clear cell cancer (n=7,positivity=100%),mucinous cystadenocarcinoma (n=6,positivity=100%),dysgerminoma (n=6,positivity=100%),squamous cell tumor (n=6,positivity=100%),sibnet-ring cell carcinoma (n=6,positivity=100%),endodermal sinus tumor (n=6,positivity=100%),germ cell tumors (n=6,positivity=100%) and immature teratoma (n=6,positivity=100%).However,PADI4 was either not detected or detected at low levels in granulosa cell tumor (n=6),malignant thecoma (n=6),ovarian cystadenoma (n=5) and normal ovarian tissue (n=11).
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