【摘 要】
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Using RNAhybrid software we investigated the antiviral effect of miR-122, on Borna Disease Virus (BDV), and found that the predicted binding of complementary sequences between miR-122 and the viral ge
【机 构】
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Department of microbiology, Harbin Medical University; Immunity and infection, Pathogenic biology Ke
论文部分内容阅读
Using RNAhybrid software we investigated the antiviral effect of miR-122, on Borna Disease Virus (BDV), and found that the predicted binding of complementary sequences between miR-122 and the viral genes and mRNAs were of crucial importance to its functions.The presence of a moderate expression level of miR-122 was identified in human oligodendroglial cells (OL), but with a much lower level of miR-122 in BDV persistent infection (OL/BDV) and cells transfected with BDV gene expression vectors.
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