• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Discovery of VEGFR2 inhibitors by integrating na(i)ve Bayesian classification, molecular docking and

Discovery of VEGFR2 inhibitors by integrating na(i)ve Bayesian classification, molecular docking and

来源 :第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018) | 被引量 : 0次 | 上传用户：syzy3106jiege
【摘 要】
：
The high morbidity and mortality of cancer make it one of the leading causes of global death,thus it is an urgent need to develop effective drugs for cancer the
【作 者】
：
De Kang Xiaocong Pang Wenwen Lian Lvjie Xu Jinhua Wang Hao Jia Baoyue Zhang Ai-Lin Liu Guan-Hua Du 
【机 构】
：
InstituteofMateriaMedica,ChineseAcademyofMedicalSciences,PekingUnionMedicalCollege,XianNongTanStreet
【出 处】
：
第九届国际分子模拟与信息技术应用学术会议(ICMS&I2018)
【发表日期】
：
2018年5期
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The high morbidity and mortality of cancer make it one of the leading causes of global death,thus it is an urgent need to develop effective drugs for cancer therapy.Vascular endothelial growth factor receptor-2 (VEGFR2) acts as a central modulator of angiogenesis,and is therefore an important pharmaceutical target for developing anti-angiogenic agents.
其他文献
Consensus Virtual Screening for the Discovery of ABA-mimicking Ligand that Promotes Drought Resistan
It is well known that the phytohormone abscisic acid (ABA) plays an important role in plant growth,leaf abscission,seed dormancy and abiotic stresses,including
会议
Analysis and Evaluation of the Inhibitory Mechanism of a Novel Angiotensin-I-Converting Enzyme Inhib
　　Casein hydrolysates exert various biological activities,and the responsible functional peptides are being identified from them continuously.In this study,th
会议
caseinACE inhibitory activitypeptidein silicoCE-TOF-MS/MSmolecular docking
On the abnormal fast diffusion of solute atoms inα-TiA first-principles investigation
Solute atoms such as Fe,Co,and Ni diffuse abnormally fast in α-Ti,which influences significantly themechanical properties of the titanium alloys.Various mechan
会议
Screening for cyclooxygenase2inhibitors from natural compounds of Radix Glycyrrhizae using computer
目的:探索甘草通过抑制环氧酶-2(COX-2)发挥抗炎作用的分子基础. 方法:运用Discovery Studio4.5系统预测化合物的分子性质,运用Ligand Profiler筛选与COX-2药效团作用的
会议
甘草天然成分环氧酶-2分子对接抗炎作用
Identification of a novel ACE-inhibitory peptide from casein and evaluation of the inhibitory mechan
　　Various bioactive peptides are continuously being identified from casein hydrolysates.In this work,a novel angiotensin I-converting enzyme(ACE)-inhibitory(A
会议
Casein peptideACE-inhibitory activityIdentificationMolecular dockingUPLC-ESI
From Lead to Drug CandidateOptimization of 3-(Phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Der
　　Herein we report the sophisticated process of structural optimization toward a previously disclosed Src inhibitor,compound 1,which showed high potency in th
会议
Discovery of Selective Protein Arginine Methyltransferase 5 (PRMT5) Inhibitors and Biological Evalua
　　PRMT5 is an important protein arginine methyltransferase that catalyzes the symmetric dimethylation of arginine resides on histones or non-histone substrate
会议
PDTCMA systems pharmacology platform of traditional Chinese medicine for psoriasis
　　Introduction: Psoriasis is a refractory skin disorder,and usually requires a lifetime control.Traditional Chinese medicine(TCM)is effective and safe for thi
会议
High throughput virtual screeningPsoriasisSystems pharmacologyTarget predicti
Molecular Basis for the High Activity and Enantioselectivity of the Carbonyl Reductase from Sporobol
　　In an effort to develop a practical method for the synthesis of optically pure 2,2,2-trifluoro-1-phenylethanol,we found that the carbonyl reductase(SSCR)fro
会议
α-haloacetophenonescarbonyl reductaseenzymatic reductionsite-directed mutagen
Discovery of New SIRT2 Inhibitors by Utilizing a Consensus DockingScoring Strategy and Structure-Act
　　SIRT2,which is a NAD+(nicotinamide adenine dinucleotide)dependent deacetylase,has been demonstrated to play an important role in the occurrence and developm
会议