Inhibitory effect of baicalin on the plasma protein binding and CYP1A2 activity induce the pharmacok

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：wilsonpfan

【摘要】

：

Aim: To elucidate the effect of baicalin on the pharmacokinetics of theophylline in rats, focusing on plasma protein binding displacement and inhibitory effect on CYP1A2 in vivo and in vitro.Methods:

【作者】

：

Na GAD Yan FANG Bing QI Lin-jing JIA Hai-ling QIAO

【机构】

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Department of Clinical Pharmacology, School of Medicine, Zhengzhou University, Zhengzhou 450052, Chi

【出处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

baicalin theophylline pharmacokinetics CYP1A2 protein binding

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Aim: To elucidate the effect of baicalin on the pharmacokinetics of theophylline in rats, focusing on plasma protein binding displacement and inhibitory effect on CYP1A2 in vivo and in vitro.Methods: This study was a randomized, three-period crossover design.Theophylline (5 mg/kg, iv) was administered to rats immediately following the injection of baicalin (450 mg/kg, given 1 time or divided into 3 times).

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Inhibitory effect of baicalin on the plasma protein binding and CYP1A2 activity induce the pharmacok

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