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5. Regulation of CYP3A4/CYP2BG/CYP2C9 transcription through nuclear receptor PXR by helicid and Its met

Regulation of CYP3A4/CYP2BG/CYP2C9 transcription through nuclear receptor PXR by helicid and Its met

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：zydwnj

【摘 要】

：

Aim: To establish and validate an in vitro system to screen drug inducers of CYP3A4,CYP2B6, and CYP2C9 and study hPXR (human pregnane X receptors)-mediated transcriptional regulation of CYP3A4, CYP2B6

【作 者】

：

Qun CHEN Hua SUN Zhi-chen PU Hua HU Hai-tang XIE 

【机 构】

：

Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital, Wuhu 241001, China

【出 处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

helicid human pregnane X receptors CYP3A4 CYP2B6 CYP2C9 

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Aim: To establish and validate an in vitro system to screen drug inducers of CYP3A4,CYP2B6, and CYP2C9 and study hPXR (human pregnane X receptors)-mediated transcriptional regulation of CYP3A4, CYP2B6, and CYP2C9 by a traditional Chinese medicine helicid and its two metabolites.

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