Backgrouds: It is few to establish a chronic kidney disease (CKD) model in nonhuman primates with glomerular and renal tubular compound injury.Methods: We selected 4 mg/kg, 2 mg/kg, 1 mg/kg and 2 mg/kg intravenous dose of adriamycin,once weekly.After one week, adriamycin was reinjected intravenously at four same doses, 2 mg/kg.Cisplatin was injected intraperitoneally at four same doses, 2 mg/kg, once two weeks.Renal function, eGFR and pathological changes were evaluated at the 120th day.Results:We found that GFR was 35% decrease with obvious increase in serum creatinine and urea nitrogen levels.Pathologically, the adriamycin and cisplatin leaded to moderate mesangial focal segmental glomerulosclerosis (FSGS) with mesangial matrix hyperplasia, renal tubular atrophy and peritubular fibrosis.Conclusions: This experimental model could represent a useful tool to better understand the pathogenesis of moderate to late stage of chronic kidney disease in humans.