Synthesis and Biological Characterization of Myristic Acid-Conjugated Thymopentin Analogs

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：fuyao698

【摘要】

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【作者】

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Yuanyan Tan Wei Wang Chunlei Wu Zhengyin Pan Guiyang Yao Lijing Fang Wu Su

【机构】

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Guangdong Key Laboratory of Nanomedicine,Institute of Biomedicine and Biotechnology,Shenzhen Institu

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

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2015年3期

【关键词】

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TP5 human serum plasma half-life immunomodulating activity

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　　Controlled release of peptides by plasma albumin is a successful strategy to extend half-life and improve their therapeutic effects.The short plasma half-life of thymopentin(TP5)has dramatically limited its clinical application for immunodeficiency diseases.Herein,a TP5 derivative was prepared by conjugating myristic acid at the C-terminal(TP5-MA).

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Synthesis and Biological Characterization of Myristic Acid-Conjugated Thymopentin Analogs

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